Tests for DNA and chromosomal damage induced by nuclear magnetic resonance imaging

Chinese hamster ovary (CHO) cells in culture were exposed in a nuclear magnetic resonance (NMR) imaging apparatus to a strong magnetic field, pulsed field gradients, and radio frequency emissions. No chromosomal aberrations were induced even after an exposure of approximately 14 hours. No sister chromatid exchanges were induced by four-hour exposures to either low (average 7.2 mW) or high (average 61.2 mW) radio frequency power. When HeLa cells were exposed for 16 hours to an average radio frequency power of 61.2 mW, no inhibition of DNA synthesis was detectable. These data indicate that the conditions used for NMR imaging do not cause genetic damage which is detectable by any of these methods.