Effects of endotoxin-tolerance on in vivo drug metabolism in mice

Acute doses of endotoxin and the induction of endotoxin-tolerance lowered the apparent in vivo rates of hexobarbital and zoxazolamine metabolism in mice. Acute doses of endotoxin increased the duration of narcosis induced by these two compounds to a greater extent than did induction of the endotoxin-tolerant state. In endotoxin-tolerant mice, however, acute endotoxin treatment did not extend hexobarbital sleeping or zoxazolamine paralysis times beyond those noted in endotoxin-tolerant mice given no acute endotoxin.