[Progression of new transplantable hepatomas in C3HA strain mice. II. Hepatomas 1676]

Seven new morphologically different strains of stabilized transplantable hepatomas were obtained, using a continuous subcutaneous transplantation of a highly differentiated orthoaminoazotoluol-induced primary hepatoma by the method of parallel sublines. Morphology and biological properties of all substrains are described. Differences between substrains of the highly differentiated primary hepatoma, according to their biological properties and morphology, were greater than those between substrains obtained by transplantation of a lowly differentiated primary hepatoma as a parent tumour. Some aspects of differentiation of hepatomas during their progression and stabilization are discussed.