Bilateral neuralgic amyotrophy complicating Weil's disease

Area of Science:

• Neurology
• Infectious Diseases
• Clinical Case Study

Background:

• Leptospirosis is a bacterial zoonotic disease with diverse clinical manifestations.
• Neurological complications of leptospirosis can occur, sometimes with delayed onset.
• Trimethoprim is an antibiotic used in treating bacterial infections.

Purpose of the Study:

• To describe a case of leptospirosis with late-onset neurological complications.
• To analyze the specific manifestation of bilateral plexus syndrome.
• To discuss potential reasons for persistent anterior interosseus nerve weakness.

Main Methods:

• Case report presentation.
• Clinical examination and assessment of neurological deficits.
• Discussion of pathophysiological mechanisms related to nerve injury in leptospirosis.

Main Results:

• A patient treated for leptospirosis developed late neurological complications.
• The patient presented with a bilateral plexus syndrome.
• Persistent weakness was noted in muscles supplied by the anterior interosseus nerve, while proximal muscles improved.

Conclusions:

• Leptospirosis can lead to delayed neurological sequelae, including plexus syndromes.
• The anterior interosseus nerve may be particularly vulnerable to persistent deficits.
• Further investigation into the mechanisms of post-leptospirosis neuropathy is warranted.