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Related Experiment Videos

Delayed hemolytic transfusion reaction presenting as sickle-cell crisis

W J Diamond, F L Brown, P Bitterman

    Annals of Internal Medicine
    |August 1, 1980
    PubMed
    Summary

    Delayed hemolytic reactions can occur after blood transfusions in sickle-cell disease patients. These reactions, linked to antibodies, may mimic severe sickle crises and warrant careful monitoring.

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    Area of Science:

    • Hematology
    • Transfusion Medicine
    • Immunology

    Background:

    • Sickle-cell disease patients often require transfusions.
    • Delayed hemolytic reactions (DHRs) are a known complication.
    • Identifying risk factors for DHRs is crucial for patient safety.

    Observation:

    • Partial exchange transfusion was performed on 18 sickle-cell disease patients.
    • Three patients experienced DHRs within six days post-transfusion.
    • Two severe reactions were linked to anti-Jka antibodies, presenting with serum sickness-like symptoms.

    Findings:

    • DHRs in sickle-cell disease patients can present as severe painful crises.
    • Antibodies to Kidd (Jka) antigen were associated with the most severe reactions.
    • Patients with a history of alloantibody formation are at higher risk for DHRs.

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    Implications:

    • DHRs may be underdiagnosed in sickle-cell disease patients.
    • Suspect DHRs in patients with recurrent or severe sickle crises post-transfusion.
    • Prioritize non-immunogenic blood products, especially for patients with known alloantibody production.