[Characteristics of lincomycin penetration into the organs and tissues of laboratory animals]

The study on the pharmacokinetics of lincomycin and its 7-chloroderivative in rabbits and albino mice treated with the antibiotics in single and repeated doses administered parenterally or orally revealed significant differences in distribution of the drugs in the animals. The excretion rate of the lincomycins in the rabbits was much lower. They were mainly deposited in the intestine. This fact is probably one of the causes of diarrhea and colitis developing in the course of therapy with these drugs.