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Hemodynamic significance of vasopressin in the newborn infant
In 21 normal deliveries, high concentrations of arginine vasopressin in cord arterial blood were associated with higher blood pressure and lower skin temperatures, indicating peripheral vasoconstriction. Following cesarean section after the onset of labor, cord AVP concentrations and blood pressures were lower than after normal delivery, but higher than after elective cesarean section. Maternal AVP concentrations at delivery were normal, as were plasma AVP concentrations in all infants three days after delivery. We conclude that the massive release of vasopressin is associated with normal delivery, and with peripheral vasoconstriction. These findings reflect favorable hemodynamic adaptation to the hypoxia and stress of delivery, intended to redistribute cardiac output to vital organs.
In 21 normal deliveries, high concentrations of arginine vasopressin in cord arterial blood were associated with higher blood pressure and lower skin temperatures, indicating peripheral vasoconstriction. Following cesarean section after the onset of labor, cord AVP concentrations and blood pressures were lower than after normal delivery, but higher than after elective cesarean section. Maternal AVP concentrations at delivery were normal, as were plasma AVP concentrations in all infants three days after delivery. We conclude that the massive release of vasopressin is associated with normal delivery, and with peripheral vasoconstriction. These findings reflect favorable hemodynamic adaptation to the hypoxia and stress of delivery, intended to redistribute cardiac output to vital organs.