The effects of prostaglandins on aqueous humor dynamics

PGE2, applied topically to the cornea of enucleated, arterially perfused cat eyes, produced an increase in the rate of aqueous humor (AH) production but only minimal changes in eye pressure, as observed in vivo. In contrast, PGE1, E2 and F2 alpha, administered intrarterially, induced no change in AH productin or arterial perfusate flow rate. In eyes which the AH inflow rate had been accelerated by prior administration of acetylcholine plus eserine, PGE1, E2 and F2 alpha caused a lowering of the inflow rate as well as vascular dilatation.