[Functional results of transsphenoidal selective adenomectomy in acromegaly (40 cases)]

Forty acromegalic patients were investigated before, during and after transsphenoidal selective adenomectomy. Pre- and post-operative studies were based on HGH basal levels, OGTT, TRH and LRH stimulation tests, while HGH plasma variations were measured during operation. Selective adenomectomy normalized HGH levels in 70% of all cases (89.5% in grades I-II and 52.4% in grades III-IV); moreover in these cases, OGTT documented normal control of GH secretion. Per-operative GH levels evolution proved to be of pronostic value. Stimulation tests demonstrated normal regulation of other pituitary functions.