[Main forms and stages in the development of diffuse polyposis of the large intestine (problems of classification)]

Diffuse polyposis of the large intestine is a hereditary disease involving mostly young people and characterized by a high index of malignization. Previously proposed various classifications of the disease do not reflect completely the numerous important aspects of this pathology. On the basis of macro- and miroscopic studies on 186 operation preparations of the large intestine removed for diffuse polyposis 4 groups of the disease were distinguished: I--the largest group including polyposis with predominance of the cell proliferation processes (various kinds of adenomas--147 observations), II--polyposis with prevalence of secretion processes (juvenile polyps--24 observations), III--polyposis with both signs (10 observations); in this mixed group juvenile polyps alternated with glandular and glandular-villous polyps; group IV included 5 observations with Peuts-Jeghers syndrome.