Angioimmunoblastic lymphadenopathy. Its occurrence with meningeal involvement

Area of Science:

• Neurology
• Oncology
• Immunology

Background:

• Angioimmunoblastic lymphadenopathy (AILD) is a rare peripheral T-cell lymphoma.
• AILD typically presents with generalized lymphadenopathy, hepatosplenomegaly, and immune dysregulation.

Observation:

• This case details AILD with unusual involvement of the central nervous system, specifically the leptomeninges and lumbosacral nerve roots.
• The patient presented with neurological deficits attributable to this meningeal and nerve root infiltration.

Findings:

• The study investigated a rare presentation of AILD.
• Clinical improvement was observed following the administration of systemic corticosteroids, suggesting a potential therapeutic role.

Implications:

• This case highlights the importance of considering AILD in the differential diagnosis of unexplained neurological symptoms, particularly meningeal enhancement.
• Corticosteroid therapy may be a viable treatment option for AILD involving the central nervous system.