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Glycine metabolism and glycine synthase activity during the postnatal development of rat brain
Developmental Neuroscience
|January 1, 1980
Abstract:
Glycine synthase from rat brain mitochondria shows an apparent Km for glycine of 2.6 mM. Glycine synthase from rat brain homogenate has a maximum of activity at the 10th day of life. However, each area of the central nervous system shows a different developmental pattern of glycine synthase activity. Both the 14CO2 production from (U-14C)-glycine and the incorporation of the radioactivity from the (U-14C)-glycine to the acid-insoluble fraction by cortex slices has a developmental profile similar to the glycine synthase activity in this area, having a maximum on the 10th day.
