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Updated: Aug 31, 2026

Determining the Phagocytic Activity of Clinical Antibody Samples
09:05

Determining the Phagocytic Activity of Clinical Antibody Samples

Published on: November 30, 2011

Effects of soluble immune complexes on Fc receptor- and C3b receptor-mediated phagocytosis by macrophages

F M Griffin

    The Journal of Experimental Medicine
    |October 1, 1980
    PubMed

    The effects of ingestion of soluble immune complexes upon macrophage phagocytic function was studied. Ingestion of immune complexes severely impaired the macrophage's ability to ingest IgG-coated particles but did not alter its ability to interact with particles by means other than its Fc receptors. Treatment of macrophages that had ingested immune complexes with supernates containing the previously described lymphokine that augments macrophage complement receptor function failed to enhance the cells' interaction with either IgG-coated erythrocytes or zymosan particles but markedly enhanced their ability to phagocytize via their complement receptors. The possible significance of these findings in immunologically mediated inflammation is discussed.

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