Effect of model traumatic injury on hepatic drug-metabolizing enzymes

Abdominal aorta ligation in rats was found to be a suitable model traumatic injury for the study of the effect of trauma on drug-metabolizing enzymes. This procedure was found to result in a rapid decrease in both cytochrome P-450 and mixed function amine oxidase activities. Recovery of mixed function amine oxidase activity was slower than recovery of cytochrome P-450 activity.