Related Experiment Video

Updated: Aug 6, 2026

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA
10:40

Assembly of Nucleosomal Arrays from Recombinant Core Histones and Nucleosome Positioning DNA

Published on: September 10, 2013

A low resolution structure for the histone core of the nucleosome

A Klug, D Rhodes, J Smith

    Nature
    |October 9, 1980
    PubMed

    More Related Videos

    Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging09:52

    Probing The Structure And Dynamics Of Nucleosomes Using Atomic Force Microscopy Imaging

    Published on: January 31, 2019

    In Situ Nucleosome Assembly for Single-Molecule Correlative Force and Fluorescence Microscopy05:58

    In Situ Nucleosome Assembly for Single-Molecule Correlative Force and Fluorescence Microscopy

    Published on: September 6, 2024

    Related Concept Videos

    The Nucleosome02:33

    The Nucleosome

    DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
    The Nucleosome Core Particle02:10

    The Nucleosome Core Particle

    Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
    The paradox
    Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their main responsibility is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. While on the other hand, they must allow polymerase enzymes to access DNA...
    Chromatin Packaging02:21

    Chromatin Packaging

    Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
    The chromatin
    In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
    The Nucleosome02:33

    The Nucleosome

    DNA in a human cell is almost 2m long and it is packed inside a tiny nucleus that is only a few microns in diameter. The level of compaction of DNA inside the nucleus is astonishing. It is organized into several sequentially higher levels of compaction to fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
    The Nucleosome01:19

    The Nucleosome

    Human DNA is almost two meters long. However, it is compressed inside a tiny nucleus measuring only a few microns in diameter. To make this degree of compaction possible, DNA is organized into several sequential levels so that it can fit into such a tiny space. The most compact form of DNA is a chromosome that can be seen under a microscope in a dividing cell.
    In a chromosome, DNA is wound twice around a protein complex called a histone octamer core, which consists of 8 histone proteins. This...
    The Nucleosome Core Particle01:12

    The Nucleosome Core Particle

    Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
    Nucleosomes, paradoxically, perform two opposite functions simultaneously. On the one hand, their primary aim is to protect the delicate DNA strands from physical damage and help achieve a higher compaction ratio. On the other hand, they must allow polymerase enzymes to access histone-bound DNA during...