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Regional intravascular sympathetic (RIS) block with guanethidine

H F Aarts, H J Hulsebosch

    The Netherlands Journal of Surgery
    |January 1, 1980
    PubMed
    Summary
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    Regional intravascular sympathetic (RIS) block using guanethidine effectively treats extremity circulatory disorders by causing vasodilatation without systemic effects. This method was evaluated in 50 patients, demonstrating its therapeutic potential.

    Area of Science:

    • Vascular Medicine
    • Pharmacology
    • Clinical Therapeutics

    Background:

    • Vasodilatation is crucial for managing peripheral circulatory disorders.
    • Existing treatments may have systemic side effects.
    • Sympathetic nervous system overactivity contributes to these conditions.

    Purpose of the Study:

    • To evaluate the efficacy and safety of regional intravascular sympathetic (RIS) block with guanethidine (Ismelin).
    • To assess the potential for systemic side effects of this localized treatment.
    • To provide clinical evidence supporting the use of RIS block for extremity circulatory disorders.

    Main Methods:

    • Regional intravascular sympathetic (RIS) block was performed using guanethidine.
    • The study included theoretical considerations and practical experience from 50 patients.

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  • Seven illustrative case reports are presented.

    • Main Results:

    • The RIS block achieved an effective sympathetic blockade in the targeted region.
    • The treatment appeared to avoid significant systemic side effects.
    • Clinical outcomes in case reports suggest therapeutic benefits.

    Conclusions:

    • Regional intravascular sympathetic (RIS) block with guanethidine is a promising method for treating peripheral circulatory disorders.
    • The technique offers localized sympathetic blockade with minimal systemic impact.
    • Further investigation and application in clinical practice are warranted.