Prostaglandin release from perfused, isolated hind legs in normal and arteriosclerotic rats

Intraarterial injection of 10 microgram noradrenaline (NA) produced a stronger increase of prostaglandin E-like material (PGE) in the outflow of isolated perfused hind legs of normal rats than of those of arteriosclerotic rats. The vasopressor effect of NA in normal rats was stronger than in arteriosclerotic rats, which could be explained on the basis of PGE release.