[Action of remantadine on virus-specific polypeptide synthesis in a Sindbis virus-infected cell culture]

Effect of remantadine (alpha-methyl-I-adamantane methylamine) on reproduction and synthesis of the virus-specific polypeptides was studied in culture of chicken embryo fibroblasts, infected with virus Syndbis. The preparation inhibited the virus reproduction as well as the formation of virus-specific proteins after addition into the cultural medium together with virus, immediately after absorption and within 1 and 2 hrs after absorption. The data obtained suggest a possibility of an immediate effect of remantadine on the synthesis of virus-specific macromolecules.