[Bromosulfan and indocyanine green test in liver-damaged rats]

The susceptibility and valuation of bromsulphthalein- and indocyanine green-test in liver damaged rats was investigated. The removal of BSP from the blood after the administration of carbon tetrachloride (0,1 ml/kg) showed already a delay after two weeks, while the content of ICG was only slightly altered. Both impaired uptake or transport mechanisms into liver cells and impaired metabolism or elimination processes can be indicated by these findings. After application of aminophenazone (340 mg/kg), resulting in histological detectable lesions of liver, an accelerated elimination of the two dyes from the blood was observed, which was significant for BSP and may be caused by an induction effect.