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Cross-tolerance between ethanol and morphine

A D Lê, J M Khanna, H Kalant

    Advances in Experimental Medicine and Biology
    |January 1, 1980
    PubMed
    Summary
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    Chronic ethanol exposure in rats led to tolerance to alcohol-induced hypothermia and cross-tolerance to morphine

    Area of Science:

    • Pharmacology
    • Neuroscience
    • Toxicology

    Background:

    • Chronic alcohol consumption can lead to physiological adaptations.
    • Drug tolerance is a well-documented phenomenon.
    • Understanding cross-tolerance is crucial for comprehending drug interactions.

    Purpose of the Study:

    • To investigate the development of tolerance to ethanol-induced hypothermia in rats.
    • To examine potential cross-tolerance between ethanol and morphine.
    • To test the hypothesis that drug tolerance is effect-specific.

    Main Methods:

    • Adult male Wistar rats were administered a liquid diet with 35% ethanol calories daily.
    • Control rats received an isocaloric sucrose-containing diet.
    • Rectal temperatures were measured after challenge doses of ethanol or morphine.

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    Main Results:

    • Rats chronically consuming ethanol showed reduced hypothermia after ethanol challenge, indicating tolerance.
    • These rats also exhibited cross-tolerance to the hypothermic effects of morphine.
    • No cross-tolerance was observed for morphine's hyperthermic effect.

    Conclusions:

    • Chronic ethanol exposure induces tolerance to its hypothermic effects.
    • Cross-tolerance between ethanol and morphine exists for hypothermic responses.
    • Drug tolerance and cross-tolerance appear to be specific to particular drug effects, not the drug itself.