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Related Experiment Videos

Ocular quinine toxicity

G S Brinton, E W Norton, J R Zahn

    American Journal of Ophthalmology
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Quinine overdose can cause severe vision loss, including blindness. While some vision may recover, long-term effects like constricted visual fields and optic nerve damage can persist.

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    Area of Science:

    • Ophthalmology
    • Toxicology

    Background:

    • Quinine is an antimalarial and antiarrhythmic drug.
    • Ingestion of large doses can lead to toxic effects, including ocular toxicity.

    Observation:

    • A 25-year-old woman experienced complete vision loss after ingesting a significant amount of quinine.
    • Fundus examination revealed mild venous distention and retinal haziness.
    • Electroretinogram, electrooculogram, and visual-evoked potential showed mild abnormalities.

    Findings:

    • Visual acuity returned to normal within two days, but with a severely constricted visual field.
    • Characteristic late signs of quinine toxicity, including retinal vascular narrowing and optic disc pallor, developed within six months.
    • Persistent visual field constriction to 12 degrees with temporal islands was noted.

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    Implications:

    • This case highlights the potential for severe and potentially permanent visual impairment following quinine overdose.
    • Ocular toxicity from quinine necessitates prompt recognition and management.
    • Long-term monitoring is crucial for patients experiencing quinine-induced visual disturbances.