[EEG effects of premedication with thalamonal. a clinical study on 16 patients (author's transl)]

Changes of EEG and cEEG have been studied in two groups of patients (n=16) premedicated with 2 ml Thalamonal iv. (dosage: 5 mg droperidol; 0.1 mg fentanyl). Study group A consisted of patients, whose age ranged from 20 to 50 years, in study group B the patients' ages were avove 70 years. EEG and cEEG observation time was 15 min in general; in a few cases on hour. Changes in clinical behaviour were registered; blood pressure and pulse-rate measurements were taken at regular intervals. The base line electroencephalogram of twelve patients was unremarkable. Four elder patients of group B showed deviations from normal. Characteristic changes in the electroencephalogram after the tested premedication were: a decent accentuation and a light shifting to lower frequency of alpha-activity; in addition a light increase of delta-frequency. In good correlation to these findings were the clinical effects of sedation and light sleep. Light side effects in behaviour were seen in one patient. The tested disage of Thalamonal i.v. lowered the blood pressure particularly in younger patients.