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[Poisoning by nalidixic acid in children]
Boletin Medico Del Hospital Infantil De Mexico
|September 1, 1980
Summary
Nalidixic acid intoxication in children, often iatrogenic, primarily affects infants under one year. Clinical signs include neurological changes, hypertensive cranial syndrome, and neuronal damage, necessitating careful drug use for urinary infections.
Area of Science:
- Pediatric Emergency Medicine
- Clinical Toxicology
- Pharmacology
Context:
- Review of 18 pediatric cases admitted to the Emergency Department of Hospital de Pediatría del C.M.N. (IMSS).
- Study period: 1976-1978 (3 years).
- Focus on nalidixic acid intoxication in children.
Purpose:
- To analyze the clinical histories of children diagnosed with nalidixic acid intoxication.
- To identify common clinical manifestations and mechanisms of intoxication.
- To review appropriate indications for nalidixic acid use.
Summary:
- Iatrogenic nalidixic acid intoxication was most frequent, particularly in infants under one year.
- Key clinical findings included altered alertness, hypertensive cranial syndrome, and neuronal damage.
- Treatment involved gastric lavage, supportive care, acid-base correction, and seizure control.
Impact:
- Highlights the risks of nalidixic acid in pediatric populations.
- Emphasizes the importance of cautious prescription for urinary tract infections.
- Informs clinical practice regarding management of nalidixic acid overdose.