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Generalized trichorrhexis nodosa

J N Leonard, C L Gummer, R P Dawber

The British Journal of Dermatology

|July 1, 1980

Summary

This summary is machine-generated.

Generalized trichorrhexis nodosa, a hair shaft defect, is linked to abnormal alpha-keratin chain formation and low cystine levels. These intrinsic hair defects make it susceptible to breakage from minor trauma.

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Area of Science:

Dermatology
Hair biology
Biochemistry

Background:

Trichorrhexis nodosa is a common hereditary hair shaft abnormality.
It is characterized by nodes along the hair shaft, leading to breakage.

Observation:

A case of generalized trichorrhexis nodosa in a male patient is presented.
Electron histochemical and keratin amino-acid analyses were performed on hair samples.

Findings:

Abnormal staining indicated a disorder in alpha-keratin chain formation within the hair cortex, specifically concerning cystine.
Keratin amino-acid analysis revealed significantly low cystine levels.
Multiple vacuoles were observed in the hair endocuticle.

Implications:

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These findings suggest intrinsic defects in keratin structure and composition contribute to trichorrhexis nodosa.
The identified cortical changes and endocuticular vacuoles likely predispose the hair to fracture upon minor chemical or physical stress.