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Response of plasma fibronectin to major body burn

J E Grossman, R H Demling, N D Duy

    The Journal of Trauma
    |November 1, 1980
    PubMed

    Insights

    Following thermal injury, fibronectin levels significantly decrease, potentially contributing to respiratory distress and sepsis. This study highlights fibronectin

    Area of Science:

    • Biochemistry
    • Immunology
    • Physiology

    Background:

    • Macrophages phagocytize particulate matter, a process dependent on fibronectin, a plasma opsonin.
    • Physical insults can lead to fibronectin depletion and reticuloendothelial system (RES) depression.
    • RES depression is linked to post-injury complications like respiratory distress syndrome and septicemia.

    Purpose of the Study:

    • To investigate fibronectin concentration changes in sheep following controlled thermal injury.
    • To explore the relationship between fibronectin levels, serum protein concentrations, and lung lymph flow.

    Main Methods:

    • Plasma fibronectin concentration was measured in sheep with chronic lung lymph fistulas.
    • Sheep were subjected to controlled thermal injury.
    • Measurements were taken at 4, 24, 48, and 72 hours post-burn.

    Main Results:

    • Fibronectin levels significantly decreased at 4, 24, 48, and 72 hours after thermal injury (p < 0.05).
    • Fibronectin concentration decreased in parallel with serum albumin, but not serum globulin.
    • Decreased fibronectin showed an inverse relationship with lung lymph flow, indicating increased pulmonary fluid filtration.

    Conclusions:

    • Controlled thermal injury in sheep leads to significant fibronectin depletion.
    • Fibronectin levels correlate inversely with pulmonary transvascular fluid filtration.
    • Further research is warranted on fibronectin's role in the pathogenesis of post-injury respiratory distress syndrome.

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