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Liver function during treatment with cefuroxime

S Iwarson, J Martinell, B Trollfors

    Scandinavian Journal of Infectious Diseases
    |January 1, 1980
    PubMed
    Summary
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    Cefuroxime treatment improved liver function in most patients, even those with initial impairment. This antibiotic appears well-tolerated, showing positive effects on galactose half-life during therapy.

    Area of Science:

    • Pharmacology
    • Hepatology
    • Clinical Medicine

    Background:

    • Liver function is crucial for drug metabolism.
    • Impaired liver function can affect drug half-life and efficacy.
    • Cefuroxime is a widely used antibiotic.

    Purpose of the Study:

    • To evaluate the effect of cefuroxime on liver function.
    • To assess the tolerability of cefuroxime in patients with pre-existing liver function impairment.

    Main Methods:

    • Studied liver function in 15 patients before and during cefuroxime treatment.
    • Monitored galactose half-life as a marker of metabolic liver function.

    Main Results:

    • Most patients showed improved galactose half-life during cefuroxime treatment.

    Related Experiment Videos

  • Four elderly patients with prolonged galactose half-life at admission normalized during therapy.
  • One patient with diabetes and prostate cancer showed a slight increase in galactose half-life.

    • Conclusions:

    • Cefuroxime treatment appears to be well-tolerated in patients with signs of impaired liver function.
    • Cefuroxime may positively impact metabolic liver function in many patients.