Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

pH-sensitive liposomes: possible clinical implications

M B Yatvin, W Kreutz, B A Horwitz

    Science (New York, N.Y.)
    |December 12, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Phytochrome regulation of greening in wild type and long-hypocotyl mutants ofArabidopsis thaliana.

    Planta·2013
    Same author

    Phase image differentiation with linear intensity output.

    Applied optics·2010
    Same author

    Fluorescence polarization microscope for automatic screening of membrane fluidity of individual cells.

    Applied optics·2010
    Same author

    Homologous expression of a mutated beta-tubulin gene does not confer benomyl resistance on Trichoderma virens.

    Journal of applied microbiology·2003
    Same author

    Serotonergic dorsal raphe neurons from obese zucker rats are hyperexcitable.

    Neuroscience·2003
    Same author

    Correlation between cortisol level and serotonin uptake in patients with chronic stress and depression.

    Cognitive, affective & behavioral neuroscience·2002
    Same journal

    Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

    Science (New York, N.Y.)·2026
    Same journal

    Local signals, systemic decline.

    Science (New York, N.Y.)·2026
    Same journal

    The mechanics of liver regeneration.

    Science (New York, N.Y.)·2026
    Same journal

    Computing in a memory with physics.

    Science (New York, N.Y.)·2026
    Same journal

    Retraction.

    Science (New York, N.Y.)·2026
    Same journal

    Making time.

    Science (New York, N.Y.)·2026
    See all related articles

    pH-sensitive liposomes loaded with palmitoyl homocysteine (PHC) enable targeted drug delivery. These liposomes release drugs effectively in lower pH environments, such as tumors and inflamed tissues, for enhanced therapeutic efficacy.

    Area of Science:

    • Biochemistry
    • Materials Science
    • Pharmacology

    Background:

    • Liposomes are versatile drug delivery vehicles.
    • pH-sensitive liposomes offer potential for targeted drug release.
    • Specific lipid compositions can modulate liposome responsiveness to pH changes.

    Purpose of the Study:

    • To construct and characterize liposomes incorporating the pH-sensitive lipid palmitoyl homocysteine (PHC).
    • To evaluate the pH-dependent drug release profile of these liposomes near physiological temperatures.
    • To assess the potential clinical utility of PHC-liposomes for targeted drug delivery.

    Main Methods:

    • Liposomes were formulated with the pH-sensitive lipid palmitoyl homocysteine (PHC).
    • Drug release assays were performed across a pH gradient (6.0 to 7.4) near physiological temperature.

    Related Experiment Videos

  • Liposome characteristics and drug release kinetics were analyzed.

    • Main Results:

    • Liposomes containing PHC demonstrated significant pH-dependent drug release.
    • The greatest pH differential for drug release was observed between pH 6.0 and 7.4.
    • Release profiles were optimized near physiological temperatures.

    Conclusions:

    • PHC-containing liposomes are effective pH-sensitive drug delivery systems.
    • These liposomes show promise for targeted drug delivery to acidic physiological sites.
    • Potential clinical applications include cancer therapy and treatment of inflammatory conditions.