[Mechanisms of cellular dedifferentiation in the adrenal cortical substance]

Hypothyreosis or the injection of actinomycin D have been shown to reduce the expression in dedifferentiation changes that take place in the fascicular and reticular zones of the adrenal gland cortex of hypophysectomized rats. The reduced intensity of such a dedifferentiation may occur due to the suppression of m-RNA synthesis, the character of the power resulting in the inhibition of DNA-dependent polymerase (actinomycin D or hypothyreosis) having no real significance.