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Dose-response study of oral fenoterol in asthmatic children
Insights
This study found that 5 mg of oral fenoterol (a beta 2-receptor stimulant) optimally improved bronchodilation in children with minimal side effects. Higher doses did not significantly increase benefits but maintained low side effect profiles.
Area of Science:
- Pediatric Pulmonology
- Pharmacology
Background:
- Beta 2-receptor stimulants are crucial for managing pediatric respiratory conditions.
- Determining optimal dosing balances efficacy and safety in children.
Purpose of the Study:
- To identify the optimal dose of oral fenoterol for bronchodilation in children.
- To evaluate the dose-response relationship for fenoterol's efficacy and side effects.
Main Methods:
- A double-blind, placebo-controlled crossover study involving 12 children.
- Comparison of three fenoterol doses (2.5, 5, 7.5 mg) and placebo over 3 hours.
- Assessment of ventilatory function, pulse rate, blood pressure, and clinical signs.
Main Results:
- Fenoterol demonstrated significant bronchodilation, peaking at 60-90 minutes.
- The 5 mg and 7.5 mg doses provided maximal bronchodilation, with no significant difference between them.
- Minimal side effects were observed across all tested doses, with no clear dose-response for cardiovascular effects.
Conclusions:
- 5 mg of oral fenoterol offers an optimal balance of bronchodilatory effect and minimal side effects in pediatric patients.
- Fenoterol is a safe and effective bronchodilator for children, with 5 mg being a recommended dose.
Abstract:
To assess the dose of oral fenoterol, a beta 2-receptor stimulant, which provided optimal bronchodilation with minimal side effects, we studied 12 children using a double-blind crossover comparison of three dose levels, 2.5, 5 and 7.5 mg, and a placebo. ventilatory function, pulse rate, blood pressure and clinical examination were compared over a 3-hour period. Administration of fenoterol resulted in bronchodilation; a maximal effect was seen at 60--90 min lasting over the period of the study. 7.5 mg of fenoterol produced the maximal bronchodilation, but it was not significantly different from 5 mg. Side effects were minimal and no significant drug-response relationship was noted for blood pressure and pulse rate. 5 mg of fenoterol provided optimal bronchodilation with minimal side effects.