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Activation of the alternative complement pathway by Histoplasma capsulatum
Infection and Immunity
|October 1, 1980
Summary
Histoplasma capsulatum yeasts activate the alternative complement pathway by consuming C3. This activation was confirmed by observing the conversion of factor B, demonstrating a key immune evasion mechanism.
Area of Science:
- Immunology
- Microbiology
Background:
- Histoplasma capsulatum is a fungal pathogen.
- The complement system is a crucial part of innate immunity.
- The alternative complement pathway plays a role in host defense against pathogens.
Purpose of the Study:
- To investigate if Histoplasma capsulatum (yeast phase) can activate the alternative complement pathway.
- To understand the interaction between H. capsulatum and the complement system.
Main Methods:
- Consumption of C3 in C4-deficient guinea pig serum by H. capsulatum yeasts.
- Immunoelectrophoretic analysis of factor B conversion.
Main Results:
- H. capsulatum yeasts consumed C3 in serum lacking C4.
- Factor B conversion confirmed C3 consumption was due to alternative pathway activation.
Conclusions:
- Histoplasma capsulatum yeast phase activates the alternative complement pathway.
- This activation may be a mechanism for H. capsulatum to evade the host immune response.