Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Silent nucleotide substitutions during evolution

T H Jukes

    Die Naturwissenschaften
    |November 1, 1980
    PubMed
    Summary

    Silent nucleotide substitutions are common in DNA evolution, especially in protein-coding genes. Non-coding DNA regions also undergo substitutions, deletions, and additions during evolution.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Mineral nutrition of plants.

    Photosynthesis research·2013
    Same author

    Further observations on choline and related compounds in nutrition.

    Federation proceedings·2010
    Same author

    Absence of appreciable L. casei factor effect in anti-pernicious anemia liver extract.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010
    Same author

    The comparative utilization of pteroylglutamic acid and pteroyltriglutamic acid by chicks on a purified diet.

    The Journal of biological chemistry·2010
    Same author

    Observations on the pteroylglutamic acid content of the tissues of chickens.

    Federation proceedings·2010
    Same author

    Acceleration of pteroylglutamic acid deficiency in mice and chicks by a chemical antagonist.

    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)·2010

    Area of Science:

    • Evolutionary biology
    • Molecular genetics
    • Genomics

    Background:

    • Silent nucleotide substitutions are crucial for understanding DNA evolution.
    • These changes occur frequently in the third codon position, preserving amino acid sequences.
    • Silent changes constitute a significant portion of substitutions in protein-coding genes.

    Purpose of the Study:

    • To analyze the prevalence and types of nucleotide substitutions in both coding and non-coding DNA regions.
    • To differentiate evolutionary mechanisms acting on different genomic compartments.

    Main Methods:

    • Comparative analysis of homologous DNA sequences from various organisms.
    • Identification and quantification of nucleotide substitutions, deletions, and additions.

    Main Results:

    • Silent nucleotide substitutions are prevalent, averaging half of all substitutions in protein-coding regions.
    • Non-coding DNA regions exhibit nucleotide substitutions, deletions, and additions, often due to recombination events.

    Conclusions:

    • Evolutionary DNA changes involve both silent substitutions and structural variations.
    • Different genomic regions are subject to distinct evolutionary pressures and mechanisms.

    Related Experiment Videos