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Updated: Aug 10, 2026
11:01
Nutrient Regulation by Continuous Feeding for Large-scale Expansion of Mammalian Cells in Spheroids
Published on: September 25, 2016
Summary
This study recalculates the energy needed for growth in infants. Synthetic processes, including RNA splicing, require 2.1% of total energy intake for a 3-week-old male infant.
Area of Science:
- Biochemistry
- Human Physiology
- Developmental Biology
Background:
- Accurate estimation of energy requirements is crucial for infant growth and development.
- Previous calculations may not fully account for the energetic costs of complex cellular processes.
Purpose of the Study:
- To recalculate the energy expenditure for synthetic processes during growth in a reference infant.
- To incorporate updated physiological parameters for oxidative phosphorylation and RNA metabolism.
Main Methods:
- Recalculation of energy requirements using physiological values for P/O ratios.
- Inclusion of energy costs for precursor RNA processing and splicing.
- Analysis based on a 3,900 g, 3-week-old male infant at the 50th percentile growth curve.
Main Results:
- Synthetic processes during growth require a specific proportion of total energy intake.
- An estimated 2.1% of total energy intake is allocated to these synthetic processes.
Conclusions:
- The updated energy requirement for synthetic processes provides a more precise understanding of infant metabolic demands.
- This finding contributes to improved nutritional guidelines and growth monitoring for infants.
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