Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Jaundice associated with naproxen

R M Victorino, J C Silveira, A Baptista

    Postgraduate Medical Journal
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Traffic-related air pollution, chronic stress, and changes in exhaled nitric oxide and lung function among a panel of children with asthma living in an underresourced community.

    The Science of the total environment·2023
    Same author

    Exposure to traffic-related air pollution and changes in exhaled nitric oxide and DNA methylation in arginase and nitric oxide synthase in children with asthma.

    Environmental health : a global access science source·2021
    Same author

    Lectins as antimicrobial agents.

    Journal of applied microbiology·2018
    Same author

    Effect of fixation time on breast biomarker expression: a controlled study using cell line-derived xenografted (CDX) tumours.

    Journal of clinical pathology·2017
    Same author

    [Psychometric approach of metacognition: Pilot study in clinical population].

    L'Encephale·2016
    Same author

    The Place of Dpp-4 Inhibitors in the Treatment Algorithm of Diabetes Type 2: A Systematic Review of Cost-Effectiveness Studies.

    Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016

    Naproxen can cause drug-induced hepatitis, a rare side effect. Stopping naproxen therapy reversed liver injury, suggesting a hypersensitivity reaction.

    Area of Science:

    • Hepatology
    • Pharmacology
    • Toxicology

    Background:

    • Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID).
    • Drug-induced liver injury (DILI) is a significant concern with NSAID use.
    • The specific mechanism of naproxen-induced hepatotoxicity is not fully understood.

    Observation:

    • A case of hepatic injury associated with naproxen therapy is presented.
    • Liver biopsy findings were consistent with drug-induced hepatitis.
    • Clinical and biochemical parameters of liver injury improved after discontinuing naproxen.

    Findings:

    • Histological examination confirmed drug-induced hepatitis.
    • Evidence suggests a hypersensitivity response to naproxen rather than direct hepatotoxicity.

    Related Experiment Videos

  • Cessation of naproxen therapy led to complete reversal of liver injury.

    • Implications:

    • This case highlights a potentially rare side effect of naproxen.
    • Increased clinician awareness may aid in identifying similar cases of naproxen-induced liver injury.
    • Further investigation into hypersensitivity reactions to naproxen is warranted.