[Changes in the amounts of incompletely oxidized metabolic products and the pathogenetic mechanisms of experimental...

The variations in the urinary excretion of half-oxidized metabolites, nonprotein nitrogen and chlorides, serum activities of LDH, MDH and ScDH, liver and kidney himogenates and histomorphologic patterns of liver, kidney and muscle tissue were studied in experimental animals, exposed to high-frequency vibrations - 100 hz. with amplitude 0.1 mm, for 60 days. The probable mechanisms of effect of the vibration factor on urinary half-oxidzed metabolite excretion are discussed. These include increased protein and carbohydrate catabolism, disturbances in the oxidoreduction processes, impairement of oxygen tissue supply, impaired urinary metabolite excretion, ect. It is suggested, after additional examination of haman subjects, to include the parameter "total amount of urinary half-oxidized metabolites" in the complex diagnosis of vibration injury in man.