Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new algorithm for clustering lymphocyte typing sera

C E Kahn, M Curie-Cohen, W H Stone

    Tissue Antigens
    |May 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genetic structure of three populations of rhesus macaques (Macaca mulatta): Implications for genetic management.

    American journal of primatology·2020
    Same author

    Imaging Informatics: 25 Years of Progress.

    Yearbook of medical informatics·2016
    Same author

    Antipsychotic agents used to augment clozapine during long-term inpatient hospitalizations.

    Pharmacopsychiatry·2014
    Same author

    Immunogenetic studies of rhesus monkeys : X. The O, P, Q, R, and S blood group systems.

    Immunogenetics·2011
    Same author

    The Harveian Oration.

    British medical journal·2010
    Same author

    Building virtual communities of practice.

    Journal of the American College of Radiology : JACR·2007
    Same journal

    Corrigendum.

    Tissue antigens·2015
    Same journal

    Nomenclature for factors of the HLA system, update September 2015.

    Tissue antigens·2015
    Same journal

    Nomenclature for factors of the HLA system, update August 2015.

    Tissue antigens·2015
    Same journal

    Nomenclature for factors of the HLA system, update July 2015.

    Tissue antigens·2015
    Same journal

    Four amino acid exchanges located in the alpha-2 domain specify the novel HLA-B*50:20 allele.

    Tissue antigens·2015
    Same journal

    A novel HLA-A*02 variant, HLA-A*02:575, detected in a Taiwanese bone marrow hematopoietic stem cell donor.

    Tissue antigens·2015
    See all related articles

    A new computer algorithm clusters antisera using a novel similarity index and central serum selection. This method improves analysis of cross-reactivity and multispecificity for better typing sera development.

    Area of Science:

    • Immunology
    • Bioinformatics
    • Computational Biology

    Background:

    • Accurate antisera clustering is crucial for immunological assays.
    • Existing methods for serum similarity assessment have limitations.

    Purpose of the Study:

    • To present a novel computer algorithm for clustering antisera.
    • To introduce an improved similarity index for comparing sera.

    Main Methods:

    • Algorithm utilizes the most centrally located serum as a reference point.
    • Serum similarity is calculated using a novel index: s = 2a/(2a + b + c) from 2x2 reaction tables.
    • Cluster and serum subsets are identified for comprehensive analysis.

    Main Results:

    • The proposed similarity index outperforms conventional measures like the correlation coefficient.

    Related Experiment Videos

  • The algorithm effectively identifies clusters and subsets of sera.
  • Analysis reveals insights into cross-reactivity and multispecificity.

    • Conclusions:

    • The developed algorithm provides a more complete analysis of antisera cross-reactivity.
    • The method aids in identifying potential absorptions to generate monospecific typing sera.
    • A computer program for this analysis is available.