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Abstract:
Rimmed vacuoles (Dubowitz and Brooke 1973) have been found in 12 cases with various neuromuscular diseases and are considered to be autophagic in nature. They consisted of multilaminated membranous structures accompanied by glycogen granules, dense bodies, and amorphous, granular, and fibrillar material. The contents of the vacuoles were regarded as having partially dissolved out of the vacuoles in cryostat sections but some were plastered along the walls of the vacuoles and were depicted by the staining procedures for light microscopy. The "lined vacuoles" described by Carpenter et al. (1978) in inclusion body myositis closely agree with the rimmed vacuoles in respect of histochemical and ultrastructural features.
Insights
Rimmed vacuoles, autophagic structures found in neuromuscular diseases, share features with inclusion body myositis vacuoles. These vacuoles contain cellular debris and membranous material.
Area of Science:
- Neuropathology
- Cell Biology
Background:
- Rimmed vacuoles are observed in various neuromuscular diseases.
- Their autophagic nature has been proposed based on ultrastructural findings.
Observation:
- These vacuoles contain multilaminated membranes, glycogen, dense bodies, and amorphous material.
- Vacuole contents appear partially dissolved in cryostat sections but are visible with light microscopy staining.
- Similar structures, termed 'lined vacuoles,' are described in inclusion body myositis.
Findings:
- Rimmed vacuoles are consistently associated with neuromuscular pathologies.
- The ultrastructural composition suggests a role in cellular degradation processes.
- Histochemical and ultrastructural similarities exist between rimmed vacuoles and those in inclusion body myositis.
Implications:
- Understanding rimmed vacuoles aids in diagnosing neuromuscular disorders.
- Further research may elucidate their specific role in disease pathogenesis.
- These findings contribute to the differential diagnosis of myopathies.