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Rimmed vacuoles

N Fukuhara, T Kumamoto, T Tsubaki

    Acta Neuropathologica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Rimmed vacuoles, autophagic structures found in neuromuscular diseases, share features with inclusion body myositis vacuoles. These vacuoles contain cellular debris and membranous material.

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    Area of Science:

    • Neuropathology
    • Cell Biology

    Background:

    • Rimmed vacuoles are observed in various neuromuscular diseases.
    • Their autophagic nature has been proposed based on ultrastructural findings.

    Observation:

    • These vacuoles contain multilaminated membranes, glycogen, dense bodies, and amorphous material.
    • Vacuole contents appear partially dissolved in cryostat sections but are visible with light microscopy staining.
    • Similar structures, termed 'lined vacuoles,' are described in inclusion body myositis.

    Findings:

    • Rimmed vacuoles are consistently associated with neuromuscular pathologies.
    • The ultrastructural composition suggests a role in cellular degradation processes.
    • Histochemical and ultrastructural similarities exist between rimmed vacuoles and those in inclusion body myositis.

    Implications:

    • Understanding rimmed vacuoles aids in diagnosing neuromuscular disorders.
    • Further research may elucidate their specific role in disease pathogenesis.
    • These findings contribute to the differential diagnosis of myopathies.