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Drug resistance in Salmonellae isolated at Chandigarh (India) during 1972-1978
Abstract:
A total of 1316 strains of Salmonella belonging to 20 serotypes isolated at P.G.I. Chandigarh (India) were tested for drug resistance. Drug resistance was noticed in 494 (38.3%) of the strains; 194 (14.8%) of these strains were resistant to one drug, while 300 (23.5%) had multiple drug resistance. All isolated strains were sensitive to gentamicin, furazolidone and nalidixic acid. Resistance to streptomycin was observed in 233 (17.7%), chloramphenicol 197 (14,9%), tetracycline 293 (22.3%), ampicillin 428 (32.5%), kanamycin 206 (15.7%), neomycin 206 (15.7%) and sulphadiazine 215 (19.9%). Multiple drug resistance was most common in S. bareilly, S. typhimurium and S. anatum serotypes. Increase in incidence of drug resistance in Salmonellae has been noticed during 1972-1978.
Insights
A study of 1316 Salmonella strains revealed significant drug resistance, with 38.3% exhibiting resistance and 23.5% showing multiple drug resistance. Gentamicin, furazolidone, and nalidixic acid remained effective against all tested Salmonella serotypes.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Background:
- Salmonella infections pose a significant public health challenge globally.
- Antimicrobial resistance in bacterial pathogens is a growing concern, complicating treatment strategies.
- Understanding drug resistance patterns in Salmonella is crucial for effective disease management and public health interventions.
Purpose of the Study:
- To investigate the prevalence and patterns of drug resistance in Salmonella serotypes isolated in India.
- To identify specific Salmonella serotypes exhibiting multiple drug resistance.
- To assess trends in Salmonella drug resistance over a defined period.
Main Methods:
- Antimicrobial susceptibility testing was performed on 1316 Salmonella strains from 20 serotypes.
- Disk diffusion or agar dilution methods were used to determine resistance to various antibiotics.
- Data analysis focused on calculating resistance percentages and identifying patterns of multiple drug resistance.
Main Results:
- 38.3% of Salmonella strains displayed drug resistance, with 23.5% showing resistance to multiple drugs.
- High resistance rates were observed for ampicillin (32.5%), tetracycline (22.3%), and sulphadiazine (19.9%).
- Salmonella serotypes S. bareilly, S. typhimurium, and S. anatum were most frequently associated with multiple drug resistance. All strains remained sensitive to gentamicin, furazolidone, and nalidixic acid.
Conclusions:
- A notable increase in Salmonella drug resistance, including multidrug resistance, was observed between 1972 and 1978.
- The emergence of multidrug-resistant Salmonella strains necessitates continuous monitoring and updated treatment guidelines.
- Gentamicin, furazolidone, and nalidixic acid represent potential therapeutic options due to sustained sensitivity in the studied Salmonella population.