Computer evaluation of cytostatic properties of compounds. II. In vitro studies on the activities by CY-VTP/2 program...

For the second step of in vivo investigation on the basis of the NCI, NIH examination procedure of cytostatics, an evaluation program CY-VTP/2 in ALGOL-1204) of cytostatic activities was prepared for the Polish ODRA-1204 computer. The program allows: a) variety of investigation in connection with possibilities of alternative usage of examination variants; b) comparison with NIC, NIH results with an optimum for verification and unification with every program; c) to obtain precise data from a great series of compounds with additional information (inactive concentration ED0, range of ED50, activities, a degree of linear correlation; d) graphic presentation of data. Program may be useful for evaluation of other effects dependent on doses and the I-range type reactions.