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Published on: August 4, 2016
An electron-microscopic study of basal cell carcinoma
The Journal of Pathology
|November 1, 1978
Summary
Electron microscopy revealed cellular polymorphism in basal cell carcinomas. Langerhans cells, a type of non-epithelial cell, were frequently observed, prompting a discussion on their role in this skin cancer.
Area of Science:
- Dermatopathology
- Immunohistochemistry
- Electron Microscopy
Background:
- Basal cell carcinoma (BCC) is the most common type of human cancer.
- The cellular composition of BCC, particularly non-epithelial components, is not fully understood.
- Langerhans cells play a role in skin immunity.
Purpose of the Study:
- To investigate the ultrastructural features of basal cell carcinomas.
- To identify and characterize non-epithelial cells within BCC.
- To explore the potential involvement of Langerhans cells in BCC pathogenesis.
Main Methods:
- Electron microscopy was used to examine 32 BCC samples.
- Cellular morphology and non-epithelial cell presence were analyzed.
- Comparative analysis with existing literature on BCC and Langerhans cells.
Main Results:
- The majority of BCC samples exhibited significant cellular polymorphism.
- Langerhans cells were the most frequently identified non-epithelial cells in the examined tumors.
- Specific ultrastructural characteristics of these Langerhans cells were noted.
Conclusions:
- The presence of numerous Langerhans cells suggests their potential role in the microenvironment of basal cell carcinoma.
- Cellular polymorphism is a common feature of BCC, as observed via electron microscopy.
- Further research is warranted to elucidate the functional significance of Langerhans cells in BCC development and progression.
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