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Rodents as laboratory hosts for schistosomes
Journal of the South African Veterinary Association
|September 1, 1978
Summary
This study lists rodent species used for culturing mammalian schistosomes at a South African research institute. It highlights the benefits of using wild, lab-adapted South African rodents and discusses infection methods.
Area of Science:
- Medical Parasitology
- Zoonotic Diseases
- Mammalian Cell Culture
Background:
- Schistosomiasis is a significant parasitic disease affecting millions globally.
- Mammalian host models are crucial for studying schistosome biology and developing treatments.
- The South African Institute for Medical Research (SAIMR) utilizes specific rodent species for schistosome research.
Purpose of the Study:
- To document the rodent species employed at SAIMR for the in vitro culture of mammalian schistosomes.
- To emphasize the advantages of utilizing wild South African rodent species adapted to laboratory settings.
- To provide insights into effective infection techniques for these models.
Main Methods:
- Compilation of rodent species records from SAIMR.
- Review of literature on laboratory adaptation of wild rodent species.
- Description of established schistosome infection protocols.
Main Results:
- A comprehensive list of rodent species utilized for schistosome culture at SAIMR is presented.
- Wild South African rodent species demonstrate significant advantages for laboratory schistosome culture.
- Specific infection techniques suitable for these rodent models are detailed.
Conclusions:
- The selection of appropriate rodent hosts is critical for successful schistosome culture and research.
- Wild, lab-adapted South African rodents offer a valuable resource for schistosomiasis research.
- Standardized infection techniques enhance the reliability of schistosome models in research settings.