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Disability and intellectual function in multiple sclerosis patients

G G Marsh

    The Journal of Nervous and Mental Disease
    |December 1, 1980
    PubMed
    Summary
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    Multiple sclerosis (MS) disability severity correlates with illness duration but not cognitive scores. MS patients showed average to bright normal intelligence, with motor-heavy tasks impacting performance.

    Area of Science:

    • Neuroscience
    • Clinical Neurology
    • Psychometrics

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease affecting cognitive function and physical abilities.
    • Understanding the relationship between disability progression and cognitive performance is crucial for patient management.
    • Previous research has explored various factors influencing cognitive deficits in MS.

    Purpose of the Study:

    • To investigate the correlation between the severity of disability in multiple sclerosis patients and their cognitive functioning.
    • To examine how factors like age, age at onset, and illness duration relate to disability status.
    • To analyze performance on specific subtests of the Wechsler Adult Intelligence Scale (WAIS) in relation to disability.

    Main Methods:

    • Forty-eight patients with multiple sclerosis were assessed using the Kurtzke Disability Status Examination (KDSE).

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  • Cognitive abilities were evaluated using the Wechsler Adult Intelligence Scale (WAIS).
  • Statistical analysis was performed to determine correlations between KDSE scores and demographic/cognitive variables.

    • Main Results:

    • Disability status scores (mean 3.98) significantly correlated only with the duration of illness (r = .33, p < .05).
    • No significant correlations were found between disability severity and patient age, age at onset, Verbal IQ, Performance IQ, or Full Scale IQ.
    • WAIS subtest scores indicated average to bright normal intelligence; performance on motor-component subtests was lower than on verbal subtests.

    Conclusions:

    • Illness duration is a significant factor associated with disability severity in multiple sclerosis patients.
    • Cognitive functioning, as measured by WAIS, is not significantly correlated with the current level of physical disability.
    • Motor-component subtests of the WAIS may be more sensitive to the impact of MS, suggesting potential motor-related cognitive interference.