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Related Experiment Videos

Metronidazole in breast milk

S H Erickson, G L Oppenheim, G H Smith

    Obstetrics and Gynecology
    |January 1, 1981
    PubMed
    Summary

    Nursing mothers treated for trichomoniasis can minimize infant exposure to metronidazole by temporarily withholding breastfeeding for 12-24 hours post-dose. This approach ensures infant safety while allowing effective treatment for lactating women.

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    Area of Science:

    • Pharmacology
    • Maternal-Child Health
    • Infectious Diseases

    Background:

    • Metronidazole is a common treatment for trichomoniasis.
    • Its use in breastfeeding mothers is often contraindicated due to potential infant exposure.
    • Limited data exists on metronidazole levels in breast milk.

    Purpose of the Study:

    • To quantify metronidazole concentrations in breast milk after a single therapeutic dose.
    • To determine a safe interval for breastfeeding after maternal metronidazole administration.
    • To evaluate a potential treatment regimen for trichomoniasis in lactating women.

    Main Methods:

    • Assayed breast milk metronidazole concentrations in 3 lactating women.
    • Administered a single 2.0-g dose of metronidazole for trichomoniasis.
    • Measured drug levels at various time points post-administration (2, 4, 12, 24 hours).

    Main Results:

    • Peak metronidazole concentrations in breast milk occurred 2-4 hours after dosing.
    • Drug levels significantly declined between 12 and 24 hours post-dose.
    • Withholding breastfeeding for 12-24 hours substantially reduces infant exposure.

    Conclusions:

    • A 12-24 hour breastfeeding interruption is a viable strategy to minimize infant metronidazole exposure.
    • This regimen may allow safe treatment of trichomoniasis in lactating women.
    • Further research could confirm the safety and efficacy of this approach.

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