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Difference in brain densities between chronic alcoholic and normal control patients

C J Golden, B Graber, I Blose

    Science (New York, N.Y.)
    |January 30, 1981
    PubMed
    Summary

    Chronic alcoholism reduces brain density, particularly affecting the dominant hemisphere's advantage over the nondominant one. This study compared brain densities in alcoholics and controls using computerized tomography scans.

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    Area of Science:

    • Neuroscience
    • Radiology

    Background:

    • Chronic alcoholism is associated with various neurological deficits.
    • Brain structural changes in alcoholism are not fully understood.

    Purpose of the Study:

    • To investigate differences in brain density between chronic alcoholics and healthy individuals.
    • To assess hemispheric differences in brain density in the context of alcoholism.

    Main Methods:

    • Utilized computerized tomography (CT) scans to measure brain densities.
    • Compared 11 chronic alcoholics with 11 age-matched healthy controls.
    • Analyzed brain density at three specific brain levels, adjusting for artifacts.

    Main Results:

    • Chronic alcoholics exhibited altered brain densities compared to controls.

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  • The typical advantage of the dominant hemisphere over the nondominant hemisphere was reduced in alcoholics.
  • Conclusions:

    • Chronic alcoholism appears to impact overall brain density.
    • Alcoholism may lead to a reduction in hemispheric asymmetry.