[Rat brain nucleotide pool in the recovery period following resuscitation]

Content of acid-extractable nucleotides was studied in rat brain within the recovery period after 3 min of "clinical death", caused by acute hemorrhage. Within 5 min after resuscitation content of adenosine triphosphate, adenosine diphosphate and pool of adenylic nucleotides was decreased in rat brain together with an increase in amount of inosine monophosphate, nucleosides and nitrous bases. These data suggest that the energy "debt" develops and an increase in degradation of adenylic derivatives takes place. Later on, within 30 min, the content of adenylic nucleotides was normalized but concentrations of inosine monophosphate, nucleosides and nitrous bases remained higher than in controls; these data suggest the intensification of turnover of purine nucleotides. Content of all the compounds studied was normalized within 24 hrs after the resuscitation. Importance of these alterations in pathogenesis of postresuscitational impairments is discussed.