[Cerebral GABA, glutamate, aspartate and transaminases in the insulin nervous syndrome]

Alterations in content of glutamate, aspartate and gamma-aminobutyric acid /GABA/ as well as in activity of some enzymes involved in amino acid transamination were studied in rat brain tissue under conditions of insulin coma and in dynamics of its treatment using glucose. The comatose state caused in the brain tissue a decrease in content of glutamate and an increase in aspartic acid content but the concentration of GABA and the activity of transaminases were unaltered. Treatment of the coma using glucose was accompanied by an increase in concentration of the amino acids studied, especially of glutamic acid as well as by a decrease in the activity of transaminases.