[Effect of botulinum toxin on catecholamine concentration in different types of skeletal muscle]

Local and general forms of botulinic intoxication of the C type were characterized by an increase in content of catecholamines in various skeletal muscles--fast, slow and mixed. The increase in content of adrenaline and noradrenaline was observed in the muscles, treated with the toxin, at the preclinical period of intoxication with the subsequent elevation as pareses and paralyses developed in local intoxication. Administration of guanidine chloride, which partially prevents the block of cholinergic stimulation, was accompanied by a decrease in the content of catecholamines in various muscles especially in the slow musculus soleus.