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Related Experiment Videos

Fever caused by hydroxyurea

J L Bauman, S Shulruff, G R Hasegawa

    Archives of Internal Medicine
    |February 1, 1981
    PubMed
    Summary
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    Hydroxyurea, a medication for psoriasis, can rarely cause drug fever. A patient experienced recurring fever linked to hydroxyurea (HU) treatment, highlighting a potential adverse effect.

    Area of Science:

    • Dermatology
    • Pharmacology
    • Internal Medicine

    Background:

    • Hydroxyurea (HU) is a medication with various therapeutic applications.
    • Drug-induced fever is a known but uncommon adverse effect of many medications.
    • The association between hydroxyurea and drug fever is rarely reported.

    Observation:

    • A patient undergoing hydroxyurea therapy for psoriasis presented with high fever.
    • The patient's fever resolved upon cessation of hydroxyurea treatment.
    • Upon re-administration of hydroxyurea, the patient's fever recurred, establishing a temporal link.

    Findings:

    • This case report documents a clear recurrence of fever upon re-challenge with hydroxyurea.
    • The findings suggest hydroxyurea as the causative agent for drug fever in this patient.

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  • The patient's clinical presentation strongly indicates a hydroxyurea-induced fever syndrome.
  • Implications:

    • Clinicians should consider hydroxyurea as a potential cause of drug fever in patients presenting with unexplained febrile episodes.
    • This case underscores the importance of thorough medication review in diagnosing drug-induced fever.
    • Further investigation into the mechanisms of hydroxyurea-induced fever may be warranted.