[Embryotoxicity and teratogenicity of phosmet in mice]

Pregnant mice were treated with Phosmet, an organophosphorus insecticide. The doses were 6.2 mg/kg body weight and 15.5 mg/kg body weight and 15.5 mg/kg body weight, together with four-per-cent ethoxose as suspension fluid. Applications were repeated between the first and 15th or between the first and eighth days of pregnancy. Some of the animals received only one single application, between the 4th and 13th days of pregnancy. Established effects, caused by the substance proper included sex shifting among living foetuses, retardation of development, and reduced ossification.