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Antithrombin III versus prothrombin in liver cirrhosis
Haemostasis
|January 1, 1981
Summary
In liver cirrhosis patients, low levels of antithrombin III and prothrombin were common. A balanced ratio between these factors may prevent blood clots, even with low antithrombin III levels.
Area of Science:
- Hepatology
- Hematology
- Coagulation Science
Background:
- Liver cirrhosis is associated with coagulopathy.
- Antithrombin III and prothrombin are key coagulation factors.
- Thrombotic complications are a concern in liver disease.
Purpose of the Study:
- To investigate the relationship between antithrombin III and prothrombin levels in liver cirrhosis patients.
- To explore the potential protective effect of the balance between these factors against thrombosis.
Main Methods:
- Observational study of 27 liver cirrhosis patients.
- Measurement of plasma antithrombin III and prothrombin levels.
Main Results:
- 20 out of 27 patients had antithrombin III and prothrombin levels below 50%.
- No thrombotic complications were observed despite low antithrombin III levels in some patients.
Conclusions:
- A close relationship exists between antithrombin III and prothrombin levels in liver cirrhosis.
- Preserved balance between antithrombin III and prothrombin may offer protection against thrombotic tendency in liver cirrhosis.