Combined effects of alcohol and lithium on body composition in the rat model

Alcohol markedly enhances Li+ retention in blood and muscle in rats taking Li and alcohol. The marked enlargement of the exchangeable Na+ space which occurs with alcohol alone, Li+ alone, and to an even greater extent with combined therapy, results from extensive mobilization of "bound" bone sodium, which is transferred to intracellular sites, demonstrably in skeletal muscle, and presumably in other cells. This 87% increase in measured intracellular Na+, and concomitant decrease in K+, would be predicted to produce profound effects on the intracellular ionic milieu, and on membrane function. Lithium is associated with a decrease in food and fluid intake, and this effect is enhanced by alcohol. However the decrease in intake did not result in nutritionally significant deficits in either group, and therefore the observed abnormalities in body composition did not result from caloric, protein, K, Na, or Ca deficiency.